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Event

Feindel Brain and Mind Seminar Series: Cortical–Subcortical Interactions Underlie Processing of Auditory Predictions Measured With 7T fMRI

Monday, October 21, 2024 13:00to14:00
Montreal Neurological Institute De Grandpre Communications Centre, 3801 rue University, Montreal, QC, H3A 2B4, CA

The Feindel Brain and Mind Seminar Series will advance the vision of Dr. William Feindel (1918–2014), Former Director of the Neuro (1972–1984), to constantly bridge the clinical and research realms. The talks will highlight the latest advances and discoveries in neuropsychology, cognitive neuroscience, and neuroimaging.

Speakers will include scientists from across The Neuro, as well as colleagues and collaborators locally and from around the world. The series is intended to provide a virtual forum for scientists and trainees to continue to foster interdisciplinary exchanges on the mechanisms, diagnosis and treatment of brain and cognitive disorders.


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Alberto Ara

Postdoctoral Fellow, The Neuro, Â鶹Çø

´¡²ú²õ³Ù°ù²¹³¦³Ù:ÌýPerception integrates both sensory inputs and internal models of the environment. In the auditory domain, predictions play a critical role because of the temporal nature of sounds. However, the precise contribution of cortical and subcortical structures in these processes and their interaction remain unclear. It is also unclear whether these brain interactions are specific to abstract rules or if they also underlie the predictive coding of local features. We used high-field 7T functional magnetic resonance imaging to investigate interactions between cortical and subcortical areas during auditory predictive processing. Volunteers listened to tone sequences in an oddball paradigm where the predictability of the deviant was manipulated. Perturbations in periodicity were also introduced to test the specificity of the response. Results indicate that both cortical and subcortical auditory structures encode high-order predictive dynamics, with the effect of predictability being strongest in the auditory cortex. These predictive dynamics were best explained by modeling a top–down information flow, in contrast to unpredicted responses. No error signals were observed to deviations of periodicity, suggesting that these responses are specific to abstract rule violations. Our results support the idea that the high-order predictive dynamics observed in subcortical areas propagate from the auditory cortex.

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The Neuro (Montreal Neurological Institute-Hospital)Ìýis a bilingual academic healthcare institution. We are aÌýÂ鶹Çø research and teaching institute; delivering high-quality patient care, as part of the Neuroscience Mission of the Â鶹Çø Health Centre.ÌýWe areÌýproud to be a Killam Institution, supported by the Killam Trusts.

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